Also I asked because this websites admins have had this discussion with me before, that regardless of what she started out as, she's a woman now. When I myself pointed out in another topic "Are we counting Poison as a woman?" to which I was told yes. Gender Identification I guess is approved here.
She's stated to have gotten a gender reassignment surgery by Street Fighter 3, so technically she actually is a woman now.
I didn't think about this until reading your comment, but you know, you're right. Mikazuki is Setsuna as Setsuna should have been: stoic, dark, tragic past, but still a functioning human being in his relationships, if a bit stilted.
To be fair, Setsuna was already basically Heero Yuy as Heero Yuy should've been.