Walles said:

As for "yayaka bakes bitter things!?" I went with the google translate suggestion, because I can't find a translation for あき that makes sense in the context. I have a bitter feeling that there's some sort of word play that goes over my head.

It's a すき.

Removed virgin killer sweater tag, as this sweater lacks the collar, and has sleeves.

The brothers are (left to right) Juushimatsu, Choromatsu, and Osomatsu, evident from their color-coding.

Jigglypuff and Mankey?

Provence said:

Has this character a name?
I as because the artist is drawing a lot of this character...

Hiwatari Makoto, according to this post.

Does role_reversal apply here?

Username watermarks like that come from weibo.

These two pages seem to be the original artist's posts: http://weibo.com/1241563893/DyXD6hY0c http://www.zcool.com.cn/work/ZMTY2ODMyNjg=.html

I added the parody tag, as this seems like a reference to the Mastercard advertisements.

I replaced the source with an archive link since the original is not a permalink and has since been changed.

https://en.wikipedia.org/wiki/Maxwell%27s_demon

╭( ･ㅂ･)و ̑̑ ぐッ！

Kyrozen said:

If she's holding a wrench, it's Akashi.

Thanks!

Need help tagging the chibi next to Rensouhou. I suspect it's a fairy, but don't know for sure.

The water bottle she's holding is brand Irohasu (い・ろ・は・す, officially romanized as "I LOHAS"), which is a pun on her name (Iroha). I feel like there may be more to it that I'm not getting though.

UNOwens said:

Hmm....I'm not 100% sure so I won't tag it as such, but I think this is Tozokuyama(?) Megumu from Kanojo ga Flag wo Oraretara. Which also means this is a boy.

Yep, you are correct.

firechikara said:

I can't figure out the second kanji after "谷" on the second panel.
Is it another way to write "Tanima/谷間"?

Yes, it's a ryakuji.

Parody of the cover of the Rolling Stones' album "Out of Our Heads".