There's something strangely disconcerting about this, but I can't describe it. Something in the way she's acting...
Also, this looks a lot like Fujino Asagami and Tomoe Enjou from Kara no Kyoukai, but I didn't think they had anything to do with each other, so I can't guess for sure.
I was about to explain my reasoning, based on them being kinda based on Fujino and Tomoe, design- and story-wise...but I literally just now after years finally noticed Sakura's pink cardigan in the corner. Oops.
In my defense, her face looks a lot different from the depictions I've seen before.